Synonyms: Calmodulin-binding transcription activator 1, CANPMR
by Jan Klos
Background
It is a calmodulin-binding transcription activator 1 coded by the gene with the same name CAMTA1. It functions as calcium sensitive regulator of gene expression. In normal conditions the expressions is found in central nervous system (cerebellum, midbrain, pons and medulla). The fusion of WWTR1–CAMTA1 gene as a result of translocation 1p36.3 and 3q25 is found in majority of cases of epithelioid hemangioendothelioma. This translocation leads to overexpression of CAMTA 1 protein.
Expression in tumors
Positive staining is seen in about 90% cases of epithelioid hemangioendothelioma. Only limited and weak nuclear reactivity is reported in a few cases of Kaposi`s sarcoma and single cases of other tumors (breast carcinoma NOS).
Staining pattern
Staining pattern is nuclear.
Application
- Confirming diagnosis of epithelioid hemangioendothelioma.
Selected references
- Sugita S, Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics. Diagn Pathol. 2016 Aug 11;11(1):75. doi: 10.1186/s13000-016-0530-2. PMID: 27515856, PMCID: PMC4982139
- CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma. Histopathology. 2015 Dec;67(6):827-35. Epub 2015 May 22. PMID: 25879300, DOI: 10.1111/his.12713
- Younes, S. CAMTA1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscamta1.html. Accessed June 4th, 2022.